Growth Factor Gene Expression Growth factor gene expression increases substantially across multiple pathways: VEGF (Vascular Endothelial Growth Factor) Shows dose-dependent increases in mesenchymal stem cells, promoting angiogenesis and blood vessel formation bFGF (Basic Fibroblast Growth Factor) Increases 230% when combined with LED irradiation at 625-635 nm wavelengths BDNF (Brain-Derived Neurotrophic Factor) Receives stimulation for nerve outgrowth and neurological support ANGPT1 (Angiopoietin 1) Increases 487% for vascular stabilization BMP-2 (Bone Morphogenetic Protein 2) Receives upregulation for bone tissue regeneration Inflammatory Pathway Suppression Inflammatory pathway suppression occurs through multiple mechanisms
Yang, H., Chen, C., Chen, H., Duan, X., Li, J., Zhou, Y., et al
Vazquez Prieto Food & Function.2020
Available from: Janssen-Cilag International NV
Each component (BPC-157, TB-500) is not FDA-approved and was removed from 503B bulk-compounding eligibility in 2024
